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2h4u
From Proteopedia
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==Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)== | ==Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)== | ||
| - | <StructureSection load='2h4u' size='340' side='right' caption='[[2h4u]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='2h4u' size='340' side='right'caption='[[2h4u]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h4u]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2h4u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4u OCA], [https://pdbe.org/2h4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4u RCSB], [https://www.ebi.ac.uk/pdbsum/2h4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ACO13_HUMAN ACO13_HUMAN] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4u_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4u_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h4u ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Acetyl-CoA hydrolase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Berglund | + | [[Category: Arrowsmith C]] |
| - | [[Category: Edwards | + | [[Category: Berglund H]] |
| - | [[Category: Ehn | + | [[Category: Edwards A]] |
| - | [[Category: Flodin | + | [[Category: Ehn M]] |
| - | [[Category: Grasslund | + | [[Category: Flodin S]] |
| - | [[Category: Hallberg | + | [[Category: Grasslund S]] |
| - | [[Category: Hammerstrom | + | [[Category: Hallberg M]] |
| - | [[Category: Hogbom | + | [[Category: Hammerstrom M]] |
| - | [[Category: Holmberg-Schiavone | + | [[Category: Hogbom M]] |
| - | [[Category: Kotenyova | + | [[Category: Holmberg-Schiavone L]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Kotenyova T]] |
| - | [[Category: Nordlund | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nyman | + | [[Category: Nordlund P]] |
| - | [[Category: Ogg | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Ogg DJ]] |
| - | + | [[Category: Persson C]] | |
| - | [[Category: Sagemark | + | [[Category: Sagemark J]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Thorsell | + | [[Category: Thorsell A-G]] |
| - | [[Category: Uppenberg | + | [[Category: Uppenberg J]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
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Current revision
Crystal Structure of Human Thioesterase Superfamily Member 2 (CASP Target)
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Edwards A | Ehn M | Flodin S | Grasslund S | Hallberg M | Hammerstrom M | Hogbom M | Holmberg-Schiavone L | Kotenyova T | Nilsson-Ehle P | Nordlund P | Nyman T | Ogg DJ | Persson C | Sagemark J | Sundstrom M | Thorsell A-G | Uppenberg J | Weigelt J
