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2h5x

From Proteopedia

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==RuvA from Mycobacterium tuberculosis==
==RuvA from Mycobacterium tuberculosis==
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<StructureSection load='2h5x' size='340' side='right' caption='[[2h5x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2h5x' size='340' side='right'caption='[[2h5x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [http://www.ebi.ac.uk/pdbsum/2h5x PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [https://pdbe.org/2h5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [https://www.ebi.ac.uk/pdbsum/2h5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5x ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RUVA_MYCTU RUVA_MYCTU] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/2h5x_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/2h5x_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h5x ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2h5x" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Large Structures]]
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[[Category: Alipio, E Z.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bursey, E.]]
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[[Category: Alipio EZ]]
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[[Category: Chandra, N R.]]
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[[Category: Bursey E]]
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[[Category: Hung, L W.]]
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[[Category: Chandra NR]]
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[[Category: Khanduja, J S.]]
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[[Category: Hung LW]]
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[[Category: Kim, C Y.]]
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[[Category: Khanduja JS]]
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[[Category: Lekin, T.]]
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[[Category: Kim CY]]
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[[Category: Muniyappa, K.]]
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[[Category: Lekin T]]
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[[Category: Prabu, J R.]]
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[[Category: Muniyappa K]]
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[[Category: Segelke, B.]]
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[[Category: Prabu JR]]
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[[Category: Terwilliger, T C.]]
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[[Category: Segelke B]]
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[[Category: Thamotharan, S.]]
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[[Category: Terwilliger TC]]
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[[Category: Toppani, D.]]
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[[Category: Thamotharan S]]
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[[Category: Vijayan, M.]]
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[[Category: Toppani D]]
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[[Category: Waldo, G S.]]
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[[Category: Vijayan M]]
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[[Category: Yu, M.]]
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[[Category: Waldo GS]]
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[[Category: Dna binding protein]]
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[[Category: Yu M]]
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[[Category: Holliday junction binding]]
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[[Category: Recombination]]
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[[Category: Ruva]]
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Current revision

RuvA from Mycobacterium tuberculosis

PDB ID 2h5x

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