This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2h7j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:53, 30 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.==
==Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.==
-
<StructureSection load='2h7j' size='340' side='right' caption='[[2h7j]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+
<StructureSection load='2h7j' size='340' side='right'caption='[[2h7j]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2h7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H7J FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2h7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H7J FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H7J:N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE'>H7J</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f1g|2f1g]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H7J:N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE'>H7J</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h7j OCA], [https://pdbe.org/2h7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h7j RCSB], [https://www.ebi.ac.uk/pdbsum/2h7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h7j ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h7j OCA], [http://pdbe.org/2h7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h7j RCSB], [http://www.ebi.ac.uk/pdbsum/2h7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h7j ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
+
[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 31:
==See Also==
==See Also==
-
*[[Cathepsin|Cathepsin]]
+
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cathepsin S]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
-
[[Category: Ellman, J A]]
+
[[Category: Ellman JA]]
-
[[Category: Hornsby, M]]
+
[[Category: Hornsby M]]
-
[[Category: Lesley, S]]
+
[[Category: Lesley S]]
-
[[Category: Patterson, A W]]
+
[[Category: Patterson AW]]
-
[[Category: Spraggon, G]]
+
[[Category: Spraggon G]]
-
[[Category: Wood, W J]]
+
[[Category: Wood WJ]]
-
[[Category: Cathepsin s]]
+
-
[[Category: Chloromethylketone]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Nonpeptidic]]
+
-
[[Category: Substrate activity screening]]
+

Current revision

Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.

PDB ID 2h7j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2h7j"
Personal tools