1mg4

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[[Image:1mg4.jpg|left|200px]]
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{{Structure
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|RELATEDENTRY=[[1mfw|1MFW]], [[1mjd|1MJD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mg4 OCA], [http://www.ebi.ac.uk/pdbsum/1mg4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mg4 RCSB]</span>
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'''STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN'''
'''STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN'''
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[[Category: Otlewski, J.]]
[[Category: Otlewski, J.]]
[[Category: Walsh, C A.]]
[[Category: Walsh, C A.]]
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[[Category: cortex development]]
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[[Category: Cortex development]]
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[[Category: dcx domain]]
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[[Category: Dcx domain]]
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[[Category: doublecortin-like kinase]]
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[[Category: Doublecortin-like kinase]]
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[[Category: microtubule bundling]]
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[[Category: Microtubule bundling]]
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[[Category: x-ray structure]]
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[[Category: X-ray structure]]
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Revision as of 21:59, 2 May 2008

Image:1mg4.jpg

Template:STRUCTURE 1mg4

STRUCTURE OF N-TERMINAL DOUBLECORTIN DOMAIN FROM DCLK: WILD TYPE PROTEIN


Overview

The doublecortin-like domains (DCX), which typically occur in tandem, are novel microtubule-binding modules. DCX tandems are found in doublecortin, a 360-residue protein expressed in migrating neurons; the doublecortin-like kinase (DCLK); the product of the RP1 gene that is responsible for a form of inherited blindness; and several other proteins. Mutations in the gene encoding doublecortin cause lissencephaly in males and the 'double-cortex syndrome' in females. We here report a solution structure of the N-terminal DCX domain of human doublecortin and a 1.5 A resolution crystal structure of the equivalent domain from human DCLK. Both show a stable, ubiquitin-like tertiary fold with distinct structural similarities to GTPase-binding domains. We also show that the C-terminal DCX domains of both proteins are only partially folded. In functional assays, the N-terminal DCX domain of doublecortin binds only to assembled microtubules, whereas the C-terminal domain binds to both microtubules and unpolymerized tubulin.

About this Structure

1MG4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The DCX-domain tandems of doublecortin and doublecortin-like kinase., Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS, Nat Struct Biol. 2003 May;10(5):324-33. PMID:12692530 Page seeded by OCA on Sat May 3 00:59:26 2008

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