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2he3
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2he3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2he3, resolution 2.10Å" /> '''Crystal structure o...) |
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| - | [[Image:2he3.gif|left|200px]]<br /> | ||
| - | <applet load="2he3" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2he3, resolution 2.10Å" /> | ||
| - | '''Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)'''<br /> | ||
| - | == | + | ==Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)== |
| - | + | <StructureSection load='2he3' size='340' side='right'caption='[[2he3]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2he3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE3 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he3 OCA], [https://pdbe.org/2he3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he3 RCSB], [https://www.ebi.ac.uk/pdbsum/2he3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he3 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/GPX2_HUMAN GPX2_HUMAN] Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. | |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2he3_consurf.spt"</scriptWhenChecked> | |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2he3 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | [ | + | |
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Glutathione peroxidase|Glutathione peroxidase]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: Johansson C]] | ||
| + | [[Category: Kavanagh KL]] | ||
| + | [[Category: Oppermann U]] | ||
| + | [[Category: Rojkova A]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)
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