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2hhl

From Proteopedia

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==Crystal structure of the human small CTD phosphatase 3 isoform 1==
==Crystal structure of the human small CTD phosphatase 3 isoform 1==
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<StructureSection load='2hhl' size='340' side='right' caption='[[2hhl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2hhl' size='340' side='right'caption='[[2hhl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hhl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HHL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hhl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HHL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ta0|1ta0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTDSPL, C3orf8, NIF1, NIFL, YA22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhl OCA], [https://pdbe.org/2hhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hhl RCSB], [https://www.ebi.ac.uk/pdbsum/2hhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hhl ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hhl TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhl OCA], [http://pdbe.org/2hhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hhl RCSB], [http://www.ebi.ac.uk/pdbsum/2hhl PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2hhl TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CTDSL_HUMAN CTDSL_HUMAN]] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:15681389</ref>
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[https://www.uniprot.org/uniprot/CTDSL_HUMAN CTDSL_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:15681389</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/2hhl_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/2hhl_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Adams, J M]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Adams JM]]
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[[Category: Atwell, S]]
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[[Category: Almo SC]]
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[[Category: Bain, K T]]
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[[Category: Atwell S]]
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[[Category: Boice, A]]
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[[Category: Bain KT]]
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[[Category: Burley, S K]]
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[[Category: Boice A]]
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[[Category: Dickey, M]]
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[[Category: Burley SK]]
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[[Category: Emtage, S]]
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[[Category: Dickey M]]
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[[Category: Gheyi, T]]
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[[Category: Emtage S]]
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[[Category: Groshong, C]]
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[[Category: Gheyi T]]
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[[Category: Malashkevich, V N]]
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[[Category: Groshong C]]
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[[Category: Structural genomic]]
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[[Category: Malashkevich VN]]
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[[Category: Ozyurt, S]]
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[[Category: Ozyurt S]]
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[[Category: Powell, A]]
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[[Category: Powell A]]
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[[Category: Ramagopal, U]]
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[[Category: Ramagopal U]]
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[[Category: Reyes, C]]
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[[Category: Reyes C]]
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[[Category: Rooney, I]]
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[[Category: Rooney I]]
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[[Category: Rutter, M E]]
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[[Category: Rutter ME]]
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[[Category: Sauder, J M]]
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[[Category: Sauder JM]]
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[[Category: Schwinn, K D]]
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[[Category: Schwinn KD]]
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[[Category: Thompson, D A]]
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[[Category: Thompson DA]]
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[[Category: Toro, R]]
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[[Category: Toro R]]
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[[Category: Wasserman, S R]]
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[[Category: Wasserman SR]]
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[[Category: Ctd phosphatase]]
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[[Category: Hydrolase]]
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[[Category: Keggins anion]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of the human small CTD phosphatase 3 isoform 1

PDB ID 2hhl

Drag the structure with the mouse to rotate

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OCA

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