Phycocyanobilin:ferredoxin oxidoreductase

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<StructureSection load='' size='350' side='right' caption='Phycocyanobilin:ferredoxin oxidoreductase complex with biliverdin IX-α (PDB entry [[3ajg]])' scene='47/478503/Cv/1'>
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<StructureSection load='3ajg' size='350' side='right' caption='Phycocyanobilin:ferredoxin oxidoreductase complex with biliverdin IX-α (PDB entry [[3ajg]])' scene=''>
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== Function ==
== Function ==
'''Phycocyanobilin:ferredoxin oxidoreductase''' (PcyA) is a member of the Fd-dependent bilin family. PcyA reduces vinyl groups of biliverdin IX-α to yield phycocyanobilin<ref>PMID:15250720</ref>. Phycocyanobilin is a pigment precursor of the light-harvesting antennae in red algae and cyanobacteria.
'''Phycocyanobilin:ferredoxin oxidoreductase''' (PcyA) is a member of the Fd-dependent bilin family. PcyA reduces vinyl groups of biliverdin IX-α to yield phycocyanobilin<ref>PMID:15250720</ref>. Phycocyanobilin is a pigment precursor of the light-harvesting antennae in red algae and cyanobacteria.
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== Structural highlights ==
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The U-shaped porphyrin-like substrate of PcyA - <scene name='47/478503/Cv/2'>biliverdin IX-α - binds between the central β sheets and the C terminal α helices</scene><ref>PMID:20946883</ref>. <scene name='47/478503/Cv/3'>Active site</scene>.
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</StructureSection>
== 3D Structures of Phycocyanobilin:ferredoxin oxidoreductase==
== 3D Structures of Phycocyanobilin:ferredoxin oxidoreductase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3ajg]], [[3i95]] – SyPcyA (mutant) + biliverdin IX – ''Synechocystis''<br />
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[[2dke]] – SyPcyA – ''Synechocystis''<br />
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[[3f0l]], [[3f0m]], [[3nb8]], [[3nb9]] – SyPcyA (mutant)<br />
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[[2d1e]], [[4qcd]] – SyPcyA + biliverdin IX<br />
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[[3ajg]], [[3i95]], [[4eoc]], [[4eod]], [[4eoe]], [[5b4h]], [[5b4i]], [[5b4j]] – SyPcyA (mutant) + biliverdin IX<br />
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[[7yk9]], [[7ykb]] – SyPcyA (mutant) + biliverdin IX – Neutron<br />
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[[3i94]] - SyPcyA + biliverdin XIII<br />
[[3ajh]] – SyPcyA (mutant) + biliverdin XIII<br />
[[3ajh]] – SyPcyA (mutant) + biliverdin XIII<br />
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[[3i94]] - SyPcyA + biliverdin XIII<br />
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[[3i8u]] – SyPcyA + biliverdin derivative<br />
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[[3f0l]], [[3fom]], [[3nb8]], [[3nb9]] – SyPcyA (mutant)<br />
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[[2g18]] – PcyA – ''Anabena''<br />
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[[3i8u]] – SyPcyA + biliverdin derivative
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== References ==
== References ==

Current revision

Phycocyanobilin:ferredoxin oxidoreductase complex with biliverdin IX-α (PDB entry 3ajg)

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3D Structures of Phycocyanobilin:ferredoxin oxidoreductase

Updated on 30-August-2023

2dke – SyPcyA – Synechocystis
3f0l, 3f0m, 3nb8, 3nb9 – SyPcyA (mutant)
2d1e, 4qcd – SyPcyA + biliverdin IX
3ajg, 3i95, 4eoc, 4eod, 4eoe, 5b4h, 5b4i, 5b4j – SyPcyA (mutant) + biliverdin IX
7yk9, 7ykb – SyPcyA (mutant) + biliverdin IX – Neutron
3i94 - SyPcyA + biliverdin XIII
3ajh – SyPcyA (mutant) + biliverdin XIII
3i8u – SyPcyA + biliverdin derivative
2g18 – PcyA – Anabena

References

  1. ↑ Tu SL, Gunn A, Toney MD, Britt RD, Lagarias JC. Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J Am Chem Soc. 2004 Jul 21;126(28):8682-93. PMID:15250720 doi:http://dx.doi.org/10.1021/ja049280z
  2. ↑ Wada K, Hagiwara Y, Yutani Y, Fukuyama K. One residue substitution in PcyA leads to unexpected changes in tetrapyrrole substrate binding. Biochem Biophys Res Commun. 2010 Nov 12;402(2):373-7. Epub 2010 Oct 12. PMID:20946883 doi:10.1016/j.bbrc.2010.10.037

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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