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2i17
From Proteopedia
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==Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K== | ==Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K== | ||
| - | <StructureSection load='2i17' size='340' side='right' caption='[[2i17]], [[Resolution|resolution]] 0.81Å' scene=''> | + | <StructureSection load='2i17' size='340' side='right'caption='[[2i17]], [[Resolution|resolution]] 0.81Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2i17]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I17 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.81Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i17 OCA], [https://pdbe.org/2i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i17 RCSB], [https://www.ebi.ac.uk/pdbsum/2i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i17 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i17_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i17_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i17 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2i17" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Aldose | + | *[[Aldose reductase 3D structures|Aldose reductase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Aldehyde reductase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cousido | + | [[Category: Large Structures]] |
| - | [[Category: Ginell | + | [[Category: Cousido A]] |
| - | [[Category: Hasemann | + | [[Category: Ginell S]] |
| - | [[Category: Joachimiak | + | [[Category: Hasemann I]] |
| - | [[Category: Lunin | + | [[Category: Joachimiak A]] |
| - | [[Category: Mitshler | + | [[Category: Lunin VY]] |
| - | [[Category: Petrova | + | [[Category: Mitshler A]] |
| - | [[Category: Podjarny | + | [[Category: Petrova T]] |
| - | [[Category: Schneider | + | [[Category: Podjarny A]] |
| - | + | [[Category: Schneider T]] | |
| - | + | ||
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Current revision
Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K
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Categories: Homo sapiens | Large Structures | Cousido A | Ginell S | Hasemann I | Joachimiak A | Lunin VY | Mitshler A | Petrova T | Podjarny A | Schneider T
