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2irm

From Proteopedia

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Current revision

Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae

Structural highlights

2irm is a 1 chain structure with sequence from Anopheles gambiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

Q7QD46_ANOGA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK. Structural genomics of protein phosphatases. J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037 doi:http://dx.doi.org/10.1007/s10969-007-9036-1

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2irm"

@@ Line 1: / Line 1: @@
 ==Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae==
-<StructureSection load='2irm' size='340' side='right' caption='[[2irm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='2irm' size='340' side='right'caption='[[2irm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2irm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IRM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2irm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IRM FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irm OCA], [http://pdbe.org/2irm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2irm RCSB], [http://www.ebi.ac.uk/pdbsum/2irm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2irm ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2irm TOPSAN]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irm OCA], [https://pdbe.org/2irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2irm RCSB], [https://www.ebi.ac.uk/pdbsum/2irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2irm ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2irm TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7QD46_ANOGA Q7QD46_ANOGA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Anoga]]
+[[Category: Anopheles gambiae]]
-[[Category: Bonanno, J B]]
+[[Category: Large Structures]]
-[[Category: Burley, S K]]
+[[Category: Bonanno JB]]
-[[Category: Freeman, J C]]
+[[Category: Burley SK]]
-[[Category: Jin, X]]
+[[Category: Freeman JC]]
-[[Category: Structural genomic]]
+[[Category: Jin X]]
-[[Category: Pelletier, L]]
+[[Category: Pelletier L]]
-[[Category: Sauder, J M]]
+[[Category: Sauder JM]]
-[[Category: Shapiro, L]]
+[[Category: Shapiro L]]
-[[Category: Wasserman, S]]
+[[Category: Wasserman S]]
-[[Category: Mitogen-activated protein kinase kinase kinase 7 interacting protein 1]]
-[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Tab1]]
-[[Category: Tak1-binding protein]]
-[[Category: Transferase]]

2irm

From Proteopedia

Current revision

Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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