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2mll

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==MISTLETOE LECTIN I FROM VISCUM ALBUM==
==MISTLETOE LECTIN I FROM VISCUM ALBUM==
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<StructureSection load='2mll' size='340' side='right' caption='[[2mll]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2mll' size='340' side='right'caption='[[2mll]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mll OCA], [http://pdbe.org/2mll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mll RCSB], [http://www.ebi.ac.uk/pdbsum/2mll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mll ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mll OCA], [https://pdbe.org/2mll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mll RCSB], [https://www.ebi.ac.uk/pdbsum/2mll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mll ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
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[https://www.uniprot.org/uniprot/ML4_VISAL ML4_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15001393</ref> <ref>PMID:1450445</ref> [UniProtKB:P81446]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2mll" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2mll" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: Betzel, C]]
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[[Category: Betzel C]]
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[[Category: Eschenburg, S]]
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[[Category: Eschenburg S]]
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[[Category: Konareva, N]]
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[[Category: Konareva N]]
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[[Category: Kornilov, V]]
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[[Category: Kornilov V]]
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[[Category: Krauspenhaar, R]]
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[[Category: Krauspenhaar R]]
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[[Category: Maier, T]]
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[[Category: Maier T]]
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[[Category: Mikailova, I]]
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[[Category: Mikailova I]]
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[[Category: Mikhailov, A]]
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[[Category: Mikhailov A]]
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[[Category: Perbandt, M]]
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[[Category: Perbandt M]]
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[[Category: Singh, T P]]
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[[Category: Singh TP]]
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[[Category: Stoeva, S]]
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[[Category: Stoeva S]]
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[[Category: Voelter, W]]
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[[Category: Voelter W]]
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[[Category: Wacker, R]]
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[[Category: Wacker R]]
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[[Category: Ribosome]]
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[[Category: Ribosome-inactivating protein type ii]]
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Current revision

MISTLETOE LECTIN I FROM VISCUM ALBUM

PDB ID 2mll

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