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2nov

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==Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target==
==Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target==
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<StructureSection load='2nov' size='340' side='right' caption='[[2nov]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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<StructureSection load='2nov' size='340' side='right'caption='[[2nov]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NOV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NOV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nov RCSB], [http://www.ebi.ac.uk/pdbsum/2nov PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nov OCA], [https://pdbe.org/2nov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nov RCSB], [https://www.ebi.ac.uk/pdbsum/2nov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nov ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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[https://www.uniprot.org/uniprot/Q3HYJ3_STREE Q3HYJ3_STREE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/2nov_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/2nov_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nov ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2nov" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Achari, A]]
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[[Category: Achari A]]
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[[Category: Ferrara, J D]]
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[[Category: Ferrara JD]]
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[[Category: Fisher, L M]]
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[[Category: Fisher LM]]
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[[Category: Laponogov, I]]
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[[Category: Laponogov I]]
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[[Category: Pan, X S]]
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[[Category: Pan XS]]
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[[Category: Sanderson, M R]]
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[[Category: Sanderson MR]]
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[[Category: Sohi, M K]]
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[[Category: Sohi MK]]
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[[Category: Veselkov, D A]]
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[[Category: Veselkov DA]]
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[[Category: Yang, C]]
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[[Category: Yang C]]
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[[Category: Dna binding]]
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[[Category: Dna cleavage]]
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[[Category: Gram-positive bacteria]]
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[[Category: Isomerase]]
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[[Category: Parc]]
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[[Category: Protein]]
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[[Category: Quinolone target]]
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[[Category: Topo iv]]
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Current revision

Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target

PDB ID 2nov

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