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2ny5

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==HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b==
==HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b==
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<StructureSection load='2ny5' size='340' side='right' caption='[[2ny5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2ny5' size='340' side='right'caption='[[2ny5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ny5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NY5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ny5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NY5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gc1|1gc1]], [[1rzj|1rzj]], [[1rzk|1rzk]], [[2nxy|2nxy]], [[2nxz|2nxz]], [[2ny0|2ny0]], [[2ny1|2ny1]], [[2ny2|2ny2]], [[2ny3|2ny3]], [[2ny4|2ny4]], [[2ny6|2ny6]], [[2ny7|2ny7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ny5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny5 OCA], [https://pdbe.org/2ny5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ny5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ny5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ny5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ny5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ny5 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
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[https://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/2ny5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ny5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ny5" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[CD4|CD4]]
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*[[CD4 3D structures|CD4 3D structures]]
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*[[Gp120|Gp120]]
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*[[Gp120 3D structures|Gp120 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Arthos, J]]
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[[Category: Large Structures]]
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[[Category: Burton, D R]]
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[[Category: Arthos J]]
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[[Category: Dey, B]]
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[[Category: Burton DR]]
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[[Category: Dimitrov, D S]]
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[[Category: Dey B]]
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[[Category: Hessell, A J]]
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[[Category: Dimitrov DS]]
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[[Category: Kwong, P D]]
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[[Category: Hessell AJ]]
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[[Category: Nabel, G J]]
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[[Category: Kwong PD]]
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[[Category: Ryk, D Van]]
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[[Category: Nabel GJ]]
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[[Category: Sodroski, J]]
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[[Category: Sodroski J]]
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[[Category: Wyatt, R]]
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[[Category: Van Ryk D]]
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[[Category: Xiang, S H]]
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[[Category: Wyatt R]]
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[[Category: Xu, L]]
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[[Category: Xiang SH]]
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[[Category: Yang, X]]
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[[Category: Xu L]]
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[[Category: Zhang, M Y]]
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[[Category: Yang X]]
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[[Category: Zhou, T]]
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[[Category: Zhang MY]]
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[[Category: Zwick, M B]]
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[[Category: Zhou T]]
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[[Category: Antibody]]
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[[Category: Zwick MB]]
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[[Category: Cd4]]
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[[Category: Gp120]]
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[[Category: Hiv]]
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[[Category: Viral protein-immune system complex]]
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Current revision

HIV-1 gp120 Envelope Glycoprotein (M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M) Complexed with CD4 and Antibody 17b

PDB ID 2ny5

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