2nzl

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[[Image:2nzl.gif|left|200px]]<br /><applet load="2nzl" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2nzl, resolution 1.35&Aring;" />
 
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'''Crystal structure of human hydroxyacid oxidase 1'''<br />
 
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==About this Structure==
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==Crystal structure of human hydroxyacid oxidase 1==
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2NZL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FMN:'>FMN</scene> and <scene name='pdbligand=GLV:'>GLV</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZL OCA].
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<StructureSection load='2nzl' size='340' side='right'caption='[[2nzl]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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[[Category: (S)-2-hydroxy-acid oxidase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2nzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZL FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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[[Category: Arrowsmith, C H.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene></td></tr>
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[[Category: Berridge, G.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzl OCA], [https://pdbe.org/2nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzl RCSB], [https://www.ebi.ac.uk/pdbsum/2nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzl ProSAT]</span></td></tr>
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[[Category: Debreczeni, J E.]]
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</table>
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[[Category: Delft, F Von.]]
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== Function ==
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[[Category: Edwards, A.]]
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[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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[[Category: Gileadi, O.]]
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== Evolutionary Conservation ==
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[[Category: Kavanagh, K.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Niesen, F.]]
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Check<jmol>
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[[Category: Oppermann, U.]]
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<jmolCheckbox>
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[[Category: Papagrigoriou, E.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzl_consurf.spt"</scriptWhenChecked>
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[[Category: Pilka, E.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: SGC, Structural Genomics Consortium.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Sundstrom, M.]]
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</jmolCheckbox>
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[[Category: Turnbull, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nzl ConSurf].
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[[Category: Ugochukwu, E.]]
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<div style="clear:both"></div>
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[[Category: Weigelt, J.]]
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[[Category: FMN]]
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[[Category: GLV]]
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[[Category: (s)-2-hydroxy-acid oxidase]]
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[[Category: glycolate oxidase]]
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[[Category: gox]]
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[[Category: gox1]]
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[[Category: haox1]]
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[[Category: hydroxyacid oxidase 1]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:12:50 2008''
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==See Also==
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*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge G]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards A]]
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[[Category: Gileadi O]]
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[[Category: Kavanagh K]]
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[[Category: Niesen F]]
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[[Category: Oppermann U]]
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[[Category: Papagrigoriou E]]
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[[Category: Pilka E]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull A]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human hydroxyacid oxidase 1

PDB ID 2nzl

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