This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2o1l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:28, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2o1l.gif|left|200px]]
 
-
{{Structure
+
==Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution==
-
|PDB= 2o1l |SIZE=350|CAPTION= <scene name='initialview01'>2o1l</scene>, resolution 1.97&Aring;
+
<StructureSection load='2o1l' size='340' side='right'caption='[[2o1l]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[2o1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O1L FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1l OCA], [https://pdbe.org/2o1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o1l RCSB], [https://www.ebi.ac.uk/pdbsum/2o1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o1l ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[2g93|2G93]], [[2hca|2HCA]], [[2dwj|2DWJ]], [[2dxy|2DXY]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1l OCA], [http://www.ebi.ac.uk/pdbsum/2o1l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o1l RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o1l_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o1l ConSurf].
 +
<div style="clear:both"></div>
-
'''Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution'''
+
==See Also==
-
 
+
*[[Lactoferrin|Lactoferrin]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2O1L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1L OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Betzel, C.]]
+
[[Category: Betzel C]]
-
[[Category: Kaur, P.]]
+
[[Category: Kaur P]]
-
[[Category: Perbandt, M.]]
+
[[Category: Perbandt M]]
-
[[Category: Sharma, S.]]
+
[[Category: Sharma S]]
-
[[Category: Singh, N.]]
+
[[Category: Singh N]]
-
[[Category: Singh, T P.]]
+
[[Category: Singh TP]]
-
[[Category: complex]]
+
-
[[Category: sugar]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:21 2008''
+

Current revision

Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution

PDB ID 2o1l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o1l"
Personal tools