2o4m

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(New page: 200px<br /><applet load="2o4m" size="350" color="white" frame="true" align="right" spinBox="true" caption="2o4m, resolution 1.640&Aring;" /> '''Structure of Phosph...)
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[[Image:2o4m.jpg|left|200px]]<br /><applet load="2o4m" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2o4m, resolution 1.640&Aring;" />
 
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'''Structure of Phosphotriesterase mutant I106G/F132G/H257Y'''<br />
 
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==About this Structure==
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==Structure of Phosphotriesterase mutant I106G/F132G/H257Y==
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2O4M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CAC:'>CAC</scene>, <scene name='pdbligand=GOL:'>GOL</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4M OCA].
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<StructureSection load='2o4m' size='340' side='right'caption='[[2o4m]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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[[Category: Aryldialkylphosphatase]]
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== Structural highlights ==
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[[Category: Brevundimonas diminuta]]
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<table><tr><td colspan='2'>[[2o4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O4M FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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[[Category: Almo, S.C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Kim, J.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4m OCA], [https://pdbe.org/2o4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4m RCSB], [https://www.ebi.ac.uk/pdbsum/2o4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4m ProSAT]</span></td></tr>
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[[Category: Ramagopal, U.A.]]
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</table>
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[[Category: Raushel, F.M.]]
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== Function ==
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[[Category: Tsai, P.]]
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[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
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[[Category: ACY]]
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== Evolutionary Conservation ==
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[[Category: CAC]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: GOL]]
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Check<jmol>
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[[Category: ZN]]
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<jmolCheckbox>
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[[Category: hydrolase]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/2o4m_consurf.spt"</scriptWhenChecked>
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[[Category: metalloenzyme]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: nerve agents]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: tim barrel]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o4m ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:33:25 2008''
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==See Also==
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*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Brevundimonas diminuta]]
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[[Category: Large Structures]]
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[[Category: Almo SC]]
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[[Category: Kim J]]
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[[Category: Ramagopal UA]]
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[[Category: Raushel FM]]
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[[Category: Tsai P]]

Current revision

Structure of Phosphotriesterase mutant I106G/F132G/H257Y

PDB ID 2o4m

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