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2o4m
From Proteopedia
(Difference between revisions)
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<StructureSection load='2o4m' size='340' side='right'caption='[[2o4m]], [[Resolution|resolution]] 1.64Å' scene=''> | <StructureSection load='2o4m' size='340' side='right'caption='[[2o4m]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2o4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O4M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4m OCA], [https://pdbe.org/2o4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4m RCSB], [https://www.ebi.ac.uk/pdbsum/2o4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4m ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4m OCA], [https://pdbe.org/2o4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4m RCSB], [https://www.ebi.ac.uk/pdbsum/2o4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Brevundimonas diminuta]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Kim | + | [[Category: Kim J]] |
| - | [[Category: Ramagopal | + | [[Category: Ramagopal UA]] |
| - | [[Category: Raushel | + | [[Category: Raushel FM]] |
| - | [[Category: Tsai | + | [[Category: Tsai P]] |
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Current revision
Structure of Phosphotriesterase mutant I106G/F132G/H257Y
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