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2oa7
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2oa7.png|left|200px]] | ||
| - | + | ==Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione== | |
| - | + | <StructureSection load='2oa7' size='340' side='right'caption='[[2oa7]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2oa7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OA7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTX:S-HEXYLGLUTATHIONE'>GTX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oa7 OCA], [https://pdbe.org/2oa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oa7 RCSB], [https://www.ebi.ac.uk/pdbsum/2oa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oa7 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GSTP1_MOUSE GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oa7_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oa7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | === | + | ==See Also== |
| - | + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Khan | + | [[Category: Khan AR]] |
| - | [[Category: Kyrieleis | + | [[Category: Kyrieleis OJ]] |
| - | [[Category: Mantle | + | [[Category: Mantle TJ]] |
| - | [[Category: McManus | + | [[Category: McManus G]] |
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Current revision
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione
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