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2ode

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==Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3==
==Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3==
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<StructureSection load='2ode' size='340' side='right' caption='[[2ode]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2ode' size='340' side='right'caption='[[2ode]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ode]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ODE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ode]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAI3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RGS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ode FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ode OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ode RCSB], [http://www.ebi.ac.uk/pdbsum/2ode PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ode FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ode OCA], [https://pdbe.org/2ode PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ode RCSB], [https://www.ebi.ac.uk/pdbsum/2ode PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ode ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1) [MIM:[http://omim.org/entry/602483 602483]]. ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.<ref>PMID:22560091</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).
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[https://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2ode_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2ode_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ode ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ode" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Guanine nucleotide-binding protein|Guanine nucleotide-binding protein]]
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von]]
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[[Category: Bunkoczi G]]
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[[Category: Doyle, D A]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Elkins, J M]]
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[[Category: Elkins JM]]
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[[Category: Gileadi, C]]
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[[Category: Gileadi C]]
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[[Category: Gorrec, F]]
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[[Category: Gorrec F]]
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[[Category: Papagrigoriou, E]]
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[[Category: Papagrigoriou E]]
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[[Category: Pike, A C.W]]
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[[Category: Pike ACW]]
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[[Category: Structural genomic]]
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[[Category: Soundararajan M]]
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[[Category: Soundararajan, M]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull AP]]
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[[Category: Turnbull, A P]]
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[[Category: Umeano C]]
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[[Category: Umeano, C]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: G protein signalling]]
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[[Category: Heterotrimeric g protein]]
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[[Category: Rg]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Signalling complex]]
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Current revision

Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

PDB ID 2ode

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