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2okt

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==Crystal structure of O-succinylbenzoic acid synthetase from Staphylococcus aureus, ligand-free form==
==Crystal structure of O-succinylbenzoic acid synthetase from Staphylococcus aureus, ligand-free form==
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<StructureSection load='2okt' size='340' side='right' caption='[[2okt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='2okt' size='340' side='right'caption='[[2okt]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2okt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OKT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2okt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKT FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">menc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/o-succinylbenzoate_synthase o-succinylbenzoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.113 4.2.1.113] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okt OCA], [https://pdbe.org/2okt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okt RCSB], [https://www.ebi.ac.uk/pdbsum/2okt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okt ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2okt TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2okt RCSB], [http://www.ebi.ac.uk/pdbsum/2okt PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2okt TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MENC_STAAC MENC_STAAC] Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Does not show N-succinylamino acid racemase (NSAR) activity with N-succinyl-L-phenylglycine as substrate (PubMed:24872444).<ref>PMID:24872444</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/2okt_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/2okt_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2okt ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2okt" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staac]]
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[[Category: Large Structures]]
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[[Category: O-succinylbenzoate synthase]]
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Burley, S K]]
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[[Category: Burley SK]]
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[[Category: Dickey, M]]
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[[Category: Dickey M]]
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[[Category: Gerlt, J]]
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[[Category: Gerlt J]]
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[[Category: Gheyi, T]]
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[[Category: Gheyi T]]
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[[Category: Malashkevich, V]]
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[[Category: Malashkevich V]]
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[[Category: Maletic, M]]
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[[Category: Maletic M]]
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[[Category: Structural genomic]]
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[[Category: Ozyurt S]]
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[[Category: Ozyurt, S]]
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[[Category: Patskovsky Y]]
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[[Category: Patskovsky, Y]]
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[[Category: Powell A]]
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[[Category: Powell, A]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M]]
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[[Category: Smith D]]
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[[Category: Smith, D]]
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[[Category: Toro R]]
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[[Category: Toro, R]]
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[[Category: Wasserman SR]]
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[[Category: Wasserman, S R]]
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[[Category: Enolase]]
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[[Category: Lyase]]
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[[Category: Nysgrc]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: O-succinylbenzoic acid synthetase]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of O-succinylbenzoic acid synthetase from Staphylococcus aureus, ligand-free form

PDB ID 2okt

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