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2orz
From Proteopedia
(Difference between revisions)
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<StructureSection load='2orz' size='340' side='right'caption='[[2orz]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='2orz' size='340' side='right'caption='[[2orz]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2orz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2orz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orz OCA], [https://pdbe.org/2orz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orz RCSB], [https://www.ebi.ac.uk/pdbsum/2orz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2orz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orz OCA], [https://pdbe.org/2orz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2orz RCSB], [https://www.ebi.ac.uk/pdbsum/2orz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2orz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NRP1_RAT NRP1_RAT] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Bellamy HD]] |
| - | [[Category: | + | [[Category: Jusino MA]] |
| - | [[Category: Leahy | + | [[Category: Leahy DJ]] |
| - | [[Category: Neau | + | [[Category: Neau DB]] |
| - | [[Category: Perman | + | [[Category: Perman B]] |
| - | [[Category: | + | [[Category: Vander Kooi CW]] |
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Current revision
Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin
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