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2oul

From Proteopedia

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{{Seed}}
 
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[[Image:2oul.png|left|200px]]
 
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==The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family==
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The line below this paragraph, containing "STRUCTURE_2oul", creates the "Structure Box" on the page.
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<StructureSection load='2oul' size='340' side='right'caption='[[2oul]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2oul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oul OCA], [https://pdbe.org/2oul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oul RCSB], [https://www.ebi.ac.uk/pdbsum/2oul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oul ProSAT]</span></td></tr>
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{{STRUCTURE_2oul| PDB=2oul | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8I6U4_PLAF7 Q8I6U4_PLAF7]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2oul_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oul ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein inhibitors of proteolytic enzymes regulate proteolysis and prevent the pathological effects of excess endogenous or exogenous proteases. Cysteine proteases are a large family of enzymes found throughout the plant and animal kingdoms. Disturbance of the equilibrium between cysteine proteases and natural inhibitors is a key event in the pathogenesis of cancer, rheumatoid arthritis, osteoporosis, and emphysema. A family (I42) of cysteine protease inhibitors (http://merops.sanger.ac.uk) was discovered in protozoan parasites and recently found widely distributed in prokaryotes and eukaryotes. We report the 2.2 A crystal structure of the signature member of the I42 family, chagasin, in complex with a cysteine protease. Chagasin has a unique variant of the immunoglobulin fold with homology to human CD8alpha. Interactions of chagasin with a target protease are reminiscent of the cystatin family inhibitors. Protein inhibitors of cysteine proteases may have evolved more than once on nonhomologous scaffolds.
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===The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family===
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The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.,Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH Structure. 2007 May;15(5):535-43. PMID:17502099<ref>PMID:17502099</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17502099}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2oul" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17502099 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_17502099}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2OUL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUL OCA].
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[[Category: Plasmodium falciparum 3D7]]
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==Reference==
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The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family., Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH, Structure. 2007 May;15(5):535-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17502099 17502099]
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[[Category: Plasmodium falciparum]]
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[[Category: Protein complex]]
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[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Chand, K.]]
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[[Category: Chand K]]
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[[Category: Fletterick, R J.]]
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[[Category: Fletterick RJ]]
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[[Category: Huang, R.]]
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[[Category: Huang R]]
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[[Category: Jacobelli, J]]
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[[Category: Jacobelli J]]
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[[Category: McKerrow, J H.]]
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[[Category: McKerrow JH]]
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[[Category: Rosenthal, P J.]]
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[[Category: Rosenthal PJ]]
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[[Category: Wang, S X.]]
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[[Category: Wang SX]]
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[[Category: Whisstock, J.]]
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[[Category: Whisstock J]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase/hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Macromolecular interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:00:51 2008''
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Current revision

The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family

PDB ID 2oul

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