This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ov2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2ov2" [edit=sysop:move=sysop])
Current revision (10:48, 30 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ov2.png|left|200px]]
 
-
{{STRUCTURE_2ov2| PDB=2ov2 | SCENE= }}
+
==The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)==
 +
<StructureSection load='2ov2' size='340' side='right'caption='[[2ov2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2ov2]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OV2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ov2 OCA], [https://pdbe.org/2ov2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ov2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ov2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ov2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ov2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ov2 ConSurf].
 +
<div style="clear:both"></div>
-
===The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)===
+
==See Also==
-
 
+
*[[Rac 3D structures|Rac 3D structures]]
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
==About this Structure==
+
== References ==
-
[[2ov2]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OV2 OCA].
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bunkoczi, G.]]
+
[[Category: Bunkoczi G]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Debreczeni, J E.D.]]
+
[[Category: Debreczeni JED]]
-
[[Category: Delft, F von.]]
+
[[Category: Doyle DA]]
-
[[Category: Doyle, D A.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Elkins JM]]
-
[[Category: Elkins, J M.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Sundstrom M]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Weigelt J]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Yang X]]
-
[[Category: Weigelt, J.]]
+
[[Category: Von Delft F]]
-
[[Category: Yang, X.]]
+
-
[[Category: Crib]]
+
-
[[Category: Gtpase rac3]]
+
-
[[Category: Kinase]]
+
-
[[Category: P21 rac]]
+
-
[[Category: Protein binding-transferase complex]]
+
-
[[Category: Ras-related c3 botulinum toxin substrate 3]]
+
-
[[Category: Sgc]]
+
-
[[Category: Signalling protein]]
+
-
[[Category: Small gtp binding protein]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+

Current revision

The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)

PDB ID 2ov2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ov2"
Personal tools