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2p0r

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[[Image:2p0r.gif|left|200px]]
 
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{{Structure
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==Structure of Human Calpain 9 in complex with Leupeptin==
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|PDB= 2p0r |SIZE=350|CAPTION= <scene name='initialview01'>2p0r</scene>, resolution 2.50&Aring;
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<StructureSection load='2p0r' size='340' side='right'caption='[[2p0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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<table><tr><td colspan='2'>[[2p0r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P0R FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE= CAPN9, NCL4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0r OCA], [https://pdbe.org/2p0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p0r RCSB], [https://www.ebi.ac.uk/pdbsum/2p0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p0r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAN9_HUMAN CAN9_HUMAN] Calcium-regulated non-lysosomal thiol-protease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p0r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p0r ConSurf].
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<div style="clear:both"></div>
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'''Structure of Human Calpain 9 in complex with Leupeptin'''
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==See Also==
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*[[Calpain 3D structures|Calpain 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2P0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0R OCA].
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[[Category: Calpain-1]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Streptomyces roseus]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Butler-Cole, C.]]
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[[Category: Bochkarev A]]
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[[Category: Davis, T L.]]
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[[Category: Butler-Cole C]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Davis TL]]
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[[Category: Edwards, A M.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Jr., P J.Finerty.]]
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[[Category: Edwards AM]]
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[[Category: Paramanathan, R.]]
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[[Category: Finerty Jr PJ]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Paramanathan R]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: CA]]
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[[Category: inhibitor complex; alpha-beta protein; hydrolase; calcium-dependent enzyme; structural genomics; structural genomics consortium; sgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:07:03 2008''
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Current revision

Structure of Human Calpain 9 in complex with Leupeptin

PDB ID 2p0r

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