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2pfr
From Proteopedia
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| - | [[Image:2pfr.gif|left|200px]]<br /><applet load="2pfr" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2pfr, resolution 1.920Å" /> | ||
| - | '''Human N-acetyltransferase 2'''<br /> | ||
| - | == | + | ==Human N-acetyltransferase 2== |
| - | + | <StructureSection load='2pfr' size='340' side='right'caption='[[2pfr]], [[Resolution|resolution]] 1.92Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2pfr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PFR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pfr OCA], [https://pdbe.org/2pfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pfr RCSB], [https://www.ebi.ac.uk/pdbsum/2pfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pfr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARY2_HUMAN ARY2_HUMAN] Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/2pfr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pfr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Arylamine N-acetyltransferase 3D structures|Arylamine N-acetyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Dombrovski | + | [[Category: Dombrovski L]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Grant | + | [[Category: Grant DM]] |
| - | [[Category: Loppnau | + | [[Category: Loppnau P]] |
| - | [[Category: Plotnikov | + | [[Category: Plotnikov AN]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Tempel W]] |
| - | [[Category: Tempel | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Wu H]] |
| - | [[Category: Wu | + | |
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Current revision
Human N-acetyltransferase 2
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Dombrovski L | Edwards AM | Grant DM | Loppnau P | Plotnikov AN | Sundstrom M | Tempel W | Weigelt J | Wu H
