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2phu

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[[Image:2phu.png|left|200px]]
 
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{{STRUCTURE_2phu| PDB=2phu | SCENE= }}
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==Pterocarpus angolensis lectin in complex with Man-8D1D3==
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<StructureSection load='2phu' size='340' side='right'caption='[[2phu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2phu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PHU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2phu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2phu OCA], [https://pdbe.org/2phu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2phu RCSB], [https://www.ebi.ac.uk/pdbsum/2phu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2phu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8GSD2_PTEAG Q8GSD2_PTEAG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/2phu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2phu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.
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===Pterocarpus angolensis lectin in complex with Man-8D1D3===
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How a plant lectin recognizes high mannose oligosaccharides.,Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:17556509<ref>PMID:17556509</ref>
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{{ABSTRACT_PUBMED_17556509}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2phu" style="background-color:#fffaf0;"></div>
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[[2phu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pterocarpus_angolensis Pterocarpus angolensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHU OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017556509</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pterocarpus angolensis]]
[[Category: Pterocarpus angolensis]]
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[[Category: Buts, L.]]
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[[Category: Buts L]]
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[[Category: Garcia-Pino, A.]]
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[[Category: Garcia-Pino A]]
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[[Category: Imberty, A.]]
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[[Category: Imberty A]]
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[[Category: Loris, R.]]
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[[Category: Loris R]]
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[[Category: Wyns, L.]]
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[[Category: Wyns L]]
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[[Category: Carbohydrate]]
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[[Category: High mannose]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Current revision

Pterocarpus angolensis lectin in complex with Man-8D1D3

PDB ID 2phu

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