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2pm5
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2pm5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pm5, resolution 2.40Å" /> '''Human alpha-defensi...) |
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| - | [[Image:2pm5.gif|left|200px]]<br /> | ||
| - | <applet load="2pm5" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2pm5, resolution 2.40Å" /> | ||
| - | '''Human alpha-defensin 1 derivative (HNP1)'''<br /> | ||
| - | == | + | ==Human alpha-defensin 1 derivative (HNP1)== |
| - | + | <StructureSection load='2pm5' size='340' side='right'caption='[[2pm5]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2pm5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PM5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pm5 OCA], [https://pdbe.org/2pm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pm5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pm5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEF3_HUMAN DEF3_HUMAN] Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.<ref>PMID:15616305</ref> <ref>PMID:2006422</ref> <ref>PMID:15894545</ref> <ref>PMID:17452329</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/2pm5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pm5 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Defensin 3D structures|Defensin 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Lu | + | [[Category: Lu W]] |
| - | [[Category: Lubkowski | + | [[Category: Lubkowski J]] |
| - | [[Category: Pazgier | + | [[Category: Pazgier M]] |
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Current revision
Human alpha-defensin 1 derivative (HNP1)
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