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2poy
From Proteopedia
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| - | [[Image:2poy.jpg|left|200px]]<br /><applet load="2poy" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2poy, resolution 1.800Å" /> | ||
| - | '''Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A'''<br /> | ||
| - | == | + | ==Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A== |
| - | + | <StructureSection load='2poy' size='340' side='right'caption='[[2poy]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2poy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum_Iowa_II Cryptosporidium parvum Iowa II] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2POY FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2poy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2poy OCA], [https://pdbe.org/2poy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2poy RCSB], [https://www.ebi.ac.uk/pdbsum/2poy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2poy ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/A3FQA7_CRYPI A3FQA7_CRYPI] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223] |
| - | [[ | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/2poy_consurf.spt"</scriptWhenChecked> |
| - | [[Category: | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2poy ConSurf]. |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Cryptosporidium parvum Iowa II]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Tolypocladium inflatum]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Artz JD]] |
| - | [[Category: | + | [[Category: Bochkarev A]] |
| - | + | [[Category: Edwards AM]] | |
| - | + | [[Category: Hassanali A]] | |
| + | [[Category: Hills T]] | ||
| + | [[Category: Hui R]] | ||
| + | [[Category: Kozieradzki I]] | ||
| + | [[Category: Lew J]] | ||
| + | [[Category: Lin YH]] | ||
| + | [[Category: Schapira M]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Wernimont AK]] | ||
| + | [[Category: Xiao T]] | ||
| + | [[Category: Zhao Y]] | ||
Current revision
Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120 in complex with cyclosporin A
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Categories: Cryptosporidium parvum Iowa II | Large Structures | Tolypocladium inflatum | Arrowsmith CH | Artz JD | Bochkarev A | Edwards AM | Hassanali A | Hills T | Hui R | Kozieradzki I | Lew J | Lin YH | Schapira M | Sundstrom M | Weigelt J | Wernimont AK | Xiao T | Zhao Y
