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2ps8

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Current revision (11:08, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2ps8' size='340' side='right'caption='[[2ps8]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
<StructureSection load='2ps8' size='340' side='right'caption='[[2ps8]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ps8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fussp Fussp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PS8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ps8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_sporotrichioides Fusarium sporotrichioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PS8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jfg|1jfg]], [[1jfa|1jfa]], [[1kiz|1kiz]], [[1yyq|1yyq]], [[2ps7|2ps7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRI5, TOX 5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5514 FUSSP])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trichodiene_synthase Trichodiene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.6 4.2.3.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ps8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ps8 OCA], [https://pdbe.org/2ps8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ps8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ps8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ps8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ps8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ps8 OCA], [https://pdbe.org/2ps8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ps8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ps8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ps8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP]] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
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[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fussp]]
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[[Category: Fusarium sporotrichioides]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trichodiene synthase]]
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[[Category: Cane DE]]
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[[Category: Cane, D E]]
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[[Category: Christianson DW]]
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[[Category: Christianson, D W]]
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[[Category: Vedula LS]]
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[[Category: Vedula, L S]]
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[[Category: Ethylene glycol]]
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[[Category: Lyase]]
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[[Category: Magnesium]]
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[[Category: Pyrophosphate]]
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[[Category: Site-directed mutagenesis]]
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[[Category: Terpenoid synthase fold]]
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Current revision

Y295F Trichodiene Synthase: Complex With Mg and Pyrophosphate

PDB ID 2ps8

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