This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2pso

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:08, 30 August 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Human StarD13 (DLC2) lipid transfer and protein localization domain==
==Human StarD13 (DLC2) lipid transfer and protein localization domain==
-
<StructureSection load='2pso' size='340' side='right' caption='[[2pso]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+
<StructureSection load='2pso' size='340' side='right'caption='[[2pso]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2pso]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSO OCA]. <br>
+
<table><tr><td colspan='2'>[[2pso]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PSO FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STARD13, DLC2, GT650 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pso OCA], [https://pdbe.org/2pso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pso RCSB], [https://www.ebi.ac.uk/pdbsum/2pso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pso ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pso RCSB], [http://www.ebi.ac.uk/pdbsum/2pso PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/STA13_HUMAN STA13_HUMAN] GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.<ref>PMID:14697242</ref> <ref>PMID:16217026</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/2pso_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/2pso_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pso ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 23: Line 25:
Comparative structural analysis of lipid binding START domains.,Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schuler H, Lehtio L PLoS One. 2011;6(6):e19521. Epub 2011 Jun 30. PMID:21738568<ref>PMID:21738568</ref>
Comparative structural analysis of lipid binding START domains.,Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schuler H, Lehtio L PLoS One. 2011;6(6):e19521. Epub 2011 Jun 30. PMID:21738568<ref>PMID:21738568</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2pso" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 30: Line 33:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Berg, S Van den.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berglund, H.]]
+
[[Category: Berglund H]]
-
[[Category: Busam, R.]]
+
[[Category: Busam R]]
-
[[Category: Collins, R.]]
+
[[Category: Collins R]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Dahlgren LG]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Flodin, S.]]
+
[[Category: Flodin S]]
-
[[Category: Flores, A.]]
+
[[Category: Flores A]]
-
[[Category: Graslund, S.]]
+
[[Category: Graslund S]]
-
[[Category: Hallberg, B M.]]
+
[[Category: Hallberg BM]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Holmberg-Schiavone, L.]]
+
[[Category: Holmberg-Schiavone L]]
-
[[Category: Johansson, I.]]
+
[[Category: Johansson I]]
-
[[Category: Kallas, A.]]
+
[[Category: Kallas A]]
-
[[Category: Karlberg, T.]]
+
[[Category: Karlberg T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Lehtio, L.]]
+
[[Category: Lehtio L]]
-
[[Category: Moche, M.]]
+
[[Category: Moche M]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nordlund P]]
-
[[Category: Nyman, T.]]
+
[[Category: Nyman T]]
-
[[Category: Ogg, D.]]
+
[[Category: Ogg D]]
-
[[Category: Persson, C.]]
+
[[Category: Persson C]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Sagemark J]]
-
[[Category: Sagemark, J.]]
+
[[Category: Stenmark P]]
-
[[Category: Stenmark, P.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Van den Berg S]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, M.]]
+
[[Category: Welin M]]
-
[[Category: Alpha and beta protein]]
+
-
[[Category: Helix swapping]]
+
-
[[Category: Lipid binding]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Unknown function]]
+

Current revision

Human StarD13 (DLC2) lipid transfer and protein localization domain

PDB ID 2pso

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pso"
Personal tools