2q9p
From Proteopedia
(Difference between revisions)
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<StructureSection load='2q9p' size='340' side='right'caption='[[2q9p]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='2q9p' size='340' side='right'caption='[[2q9p]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2q9p]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2q9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9P FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9p OCA], [https://pdbe.org/2q9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9p RCSB], [https://www.ebi.ac.uk/pdbsum/2q9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9p ProSAT]</span></td></tr> | |
| - | < | + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NUDT3_HUMAN NUDT3_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<ref>PMID:9822604</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Busam R]] |
| - | [[Category: Busam | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Dahlgren LG]] |
| - | [[Category: Dahlgren | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hallberg BM]] |
| - | [[Category: Hallberg | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Holmberg-Schiavone L]] |
| - | [[Category: Holmberg-Schiavone | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Kallas A]] |
| - | [[Category: Kallas | + | [[Category: Karlberg T]] |
| - | [[Category: Karlberg | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Lehtio L]] |
| - | [[Category: Lehtio | + | [[Category: Moche M]] |
| - | [[Category: Moche | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Ogg D]] |
| - | [[Category: Ogg | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sagemark | + | [[Category: Thorsell AG]] |
| - | [[Category: Sundstrom | + | [[Category: Van den Berg S]] |
| - | [[Category: Thorsell | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
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Current revision
Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Busam R | Collins R | Dahlgren LG | Edwards A | Flodin S | Flores A | Graslund S | Hallberg BM | Hammarstrom M | Holmberg-Schiavone L | Johansson I | Kallas A | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nordlund P | Nyman T | Ogg D | Persson C | Sagemark J | Sundstrom M | Thorsell AG | Van den Berg S | Weigelt J | Welin M
