2q9p

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(New page: 200px<br /> <applet load="2q9p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q9p, resolution 1.650&Aring;" /> '''Human diphosphoino...)
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[[Image:2q9p.gif|left|200px]]<br />
 
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<applet load="2q9p" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q9p, resolution 1.650&Aring;" />
 
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'''Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex'''<br />
 
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==About this Structure==
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==Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex==
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2Q9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, CL, F and IHP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Diphosphoinositol-polyphosphate_diphosphatase Diphosphoinositol-polyphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.52 3.6.1.52] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2Q9P OCA].
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<StructureSection load='2q9p' size='340' side='right'caption='[[2q9p]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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[[Category: Diphosphoinositol-polyphosphate diphosphatase]]
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9p OCA], [https://pdbe.org/2q9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9p RCSB], [https://www.ebi.ac.uk/pdbsum/2q9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUDT3_HUMAN NUDT3_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<ref>PMID:9822604</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9p ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S.Van.den.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Busam R]]
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[[Category: Busam, R.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Dahlgren LG]]
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[[Category: Dahlgren, L.G.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hallberg BM]]
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[[Category: Hallberg, B.M.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Kallas A]]
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[[Category: Kallas, A.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Lehtio L]]
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[[Category: Lehtio, L.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Ogg D]]
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[[Category: Ogg, D.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sagemark, J.]]
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[[Category: Thorsell AG]]
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[[Category: Sundstrom, M.]]
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[[Category: Van den Berg S]]
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[[Category: Thorsell, A.G.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: CL]]
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[[Category: F]]
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[[Category: IHP]]
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[[Category: MG]]
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[[Category: diphosphoinositol polyphosphate phosphohydrolase]]
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[[Category: inositol pyrophosphate metabolism]]
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[[Category: nudix]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:31:26 2007''
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Current revision

Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex

PDB ID 2q9p

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