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2qg1

From Proteopedia

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Current revision (11:31, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2qg1' size='340' side='right'caption='[[2qg1]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='2qg1' size='340' side='right'caption='[[2qg1]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QG1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QG1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2he2|2he2]], [[1tp3|1tp3]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qg1 OCA], [https://pdbe.org/2qg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2qg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qg1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qg1 OCA], [https://pdbe.org/2qg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2qg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qg1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
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[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Boisguerin, P]]
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[[Category: Boisguerin P]]
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[[Category: Bunkoczi, G]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von]]
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[[Category: Doyle D]]
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[[Category: Doyle, D]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C]]
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[[Category: Oschkinat H]]
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[[Category: Oschkinat, H]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E]]
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[[Category: Phillips C]]
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[[Category: Phillips, C]]
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[[Category: Salah E]]
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[[Category: Structural genomic]]
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[[Category: Savitsky P]]
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[[Category: Salah, E]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M]]
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[[Category: Uppenberg J]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J]]
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[[Category: Yang X]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Yang, X]]
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[[Category: Mpdz]]
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[[Category: Mupp1]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the 11th PDZ domain of MPDZ (MUPP1)

PDB ID 2qg1

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