2qg1

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(New page: 200px<br /> <applet load="2qg1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2qg1, resolution 1.40&Aring;" /> '''Crystal structure o...)
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[[Image:2qg1.gif|left|200px]]<br />
 
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<applet load="2qg1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qg1, resolution 1.40&Aring;" />
 
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'''Crystal structure of the 11th PDZ domain of MPDZ (MUPP1)'''<br />
 
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==About this Structure==
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==Crystal structure of the 11th PDZ domain of MPDZ (MUPP1)==
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2QG1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EDO as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2QG1 OCA].
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<StructureSection load='2qg1' size='340' side='right'caption='[[2qg1]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QG1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qg1 OCA], [https://pdbe.org/2qg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2qg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qg1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qg/2qg1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qg1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Boisguerin, P.]]
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[[Category: Boisguerin P]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F.von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J.M.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Oschkinat H]]
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[[Category: Oschkinat, H.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Salah E]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Savitsky P]]
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[[Category: Salah, E.]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P.]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M.]]
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[[Category: Uppenberg J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J.]]
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[[Category: Yang X]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Yang, X.]]
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[[Category: EDO]]
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[[Category: mpdz]]
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[[Category: mupp1]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:32:56 2007''
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Current revision

Crystal structure of the 11th PDZ domain of MPDZ (MUPP1)

PDB ID 2qg1

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