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2qj4
From Proteopedia
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==A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist== | ==A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist== | ||
| - | <StructureSection load='2qj4' size='340' side='right' caption='[[2qj4]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='2qj4' size='340' side='right'caption='[[2qj4]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qj4]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qj4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QJ4 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qj4 OCA], [https://pdbe.org/2qj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qj4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qj4 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HGF_MOUSE HGF_MOUSE] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:20624990</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qj4_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/2qj4_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qj4 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Daugherty | + | [[Category: Mus musculus]] |
| - | [[Category: Gao | + | [[Category: Daugherty J]] |
| - | [[Category: Gherardi | + | [[Category: Gao C-F]] |
| - | [[Category: Miranti | + | [[Category: Gherardi E]] |
| - | [[Category: Tolbert | + | [[Category: Miranti C]] |
| - | [[Category: Woude | + | [[Category: Tolbert WD]] |
| - | [[Category: Xe | + | [[Category: Vande Woude G]] |
| - | [[Category: Xu | + | [[Category: Xe Q]] |
| - | + | [[Category: Xu HE]] | |
| - | + | ||
| - | + | ||
Current revision
A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist
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Categories: Large Structures | Mus musculus | Daugherty J | Gao C-F | Gherardi E | Miranti C | Tolbert WD | Vande Woude G | Xe Q | Xu HE
