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2qla

From Proteopedia

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[[Image:2qla.jpg|left|200px]]<br /><applet load="2qla" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qla, resolution 2.900&Aring;" />
 
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'''Crystal Structure of a 16-Helix Bundle Architecture Produced by the Zinc-Mediated Self Assembly of Four Cytochrome cb562 Molecules'''<br />
 
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==About this Structure==
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==Crystal Structure of a 16-Helix Bundle Architecture Produced by the Zinc-Mediated Self Assembly of Four Cytochrome cb562 Molecules==
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2QLA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+500'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+C+501'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+B+502'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+D+503'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Residue+A+150'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Residue+B+151'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Residue+C+152'>AC7</scene> and <scene name='pdbsite=AC8:Hem+Binding+Site+For+Residue+D+153'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QLA OCA].
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<StructureSection load='2qla' size='340' side='right'caption='[[2qla]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qla]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QLA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qla OCA], [https://pdbe.org/2qla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qla RCSB], [https://www.ebi.ac.uk/pdbsum/2qla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qla ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ql/2qla_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qla ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Controlling protein-protein interactions through metal coordination: assembly of a 16-helix bundle protein., Salgado EN, Faraone-Mennella J, Tezcan FA, J Am Chem Soc. 2007 Nov 7;129(44):13374-5. Epub 2007 Oct 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17929927 17929927]
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*[[Cytochrome b5 3D structures|Cytochrome b5 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Faraone-Mennella, J.]]
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[[Category: Faraone-Mennella J]]
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[[Category: Salgado, E N.]]
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[[Category: Salgado EN]]
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[[Category: Tezcan, F A.]]
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[[Category: Tezcan FA]]
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[[Category: HEM]]
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[[Category: ZN]]
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[[Category: 16-helix bundle]]
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[[Category: electron transport]]
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[[Category: heme]]
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[[Category: interfacial zn-coordination]]
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[[Category: iron]]
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[[Category: metal-binding]]
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[[Category: periplasm]]
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[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:40:16 2008''
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Current revision

Crystal Structure of a 16-Helix Bundle Architecture Produced by the Zinc-Mediated Self Assembly of Four Cytochrome cb562 Molecules

PDB ID 2qla

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