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2qqk

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==Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab==
==Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab==
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<StructureSection load='2qqk' size='340' side='right' caption='[[2qqk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='2qqk' size='340' side='right'caption='[[2qqk]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qqk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QQK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qqk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QQK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qqi|2qqi]], [[2qqj|2qqj]], [[2qql|2qql]], [[2qqm|2qqm]], [[2qqn|2qqn]], [[2qqo|2qqo]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NRP2, VEGF165R2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qqk OCA], [https://pdbe.org/2qqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qqk RCSB], [https://www.ebi.ac.uk/pdbsum/2qqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qqk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qqk OCA], [http://pdbe.org/2qqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qqk RCSB], [http://www.ebi.ac.uk/pdbsum/2qqk PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NRP2_HUMAN NRP2_HUMAN]] High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
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[https://www.uniprot.org/uniprot/NRP2_HUMAN NRP2_HUMAN] High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/2qqk_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/2qqk_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
*[[Neuropilin|Neuropilin]]
*[[Neuropilin|Neuropilin]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Appleton, B A]]
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[[Category: Large Structures]]
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[[Category: Wiesmann, C]]
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[[Category: Appleton BA]]
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[[Category: Developmental protein]]
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[[Category: Wiesmann C]]
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[[Category: Differentiation]]
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[[Category: Glycoprotein]]
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[[Category: Hormone]]
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[[Category: Membrane]]
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[[Category: Neurogenesis]]
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[[Category: Phage-derived antibody]]
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[[Category: Semaphorin receptor]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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[[Category: Vegf receptor]]
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Current revision

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab

PDB ID 2qqk

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