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2r9c

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Current revision (11:50, 30 August 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2r9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2r9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GRD:BENZYL+(S)-1-((2S,3S)-1-(3-(6-AMINO-9H-PURIN-9-YL)PROPYLAMINO)-2-HYDROXY-1-OXOPENTAN-3-YLAMINO)-4-METHYL-1-OXOPENTAN-2-YLCARBAMATE'>GRD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g8j|2g8j]], [[1kxr|1kxr]], [[1tl9|1tl9]], [[1tlo|1tlo]], [[2g8e|2g8e]], [[2r9f|2r9f]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GRD:BENZYL+(S)-1-((2S,3S)-1-(3-(6-AMINO-9H-PURIN-9-YL)PROPYLAMINO)-2-HYDROXY-1-OXOPENTAN-3-YLAMINO)-4-METHYL-1-OXOPENTAN-2-YLCARBAMATE'>GRD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capn1, Cls1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9c OCA], [https://pdbe.org/2r9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9c RCSB], [https://www.ebi.ac.uk/pdbsum/2r9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9c OCA], [https://pdbe.org/2r9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9c RCSB], [https://www.ebi.ac.uk/pdbsum/2r9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT]] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
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[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calpain-1]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Campbell, R L]]
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[[Category: Campbell RL]]
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[[Category: Davies, P L]]
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[[Category: Davies PL]]
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[[Category: Qian, J]]
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[[Category: Qian J]]
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[[Category: Alpha-ketoamide]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Membrane]]
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[[Category: Peptidase]]
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[[Category: Protease]]
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[[Category: Thiol protease]]
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Current revision

Calpain 1 proteolytic core inactivated by ZLAK-3001, an alpha-ketoamide

PDB ID 2r9c

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OCA

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