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2r9m
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2r9m" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r9m, resolution 1.97Å" /> '''Cathepsin S complexe...) |
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| - | [[Image:2r9m.jpg|left|200px]]<br /><applet load="2r9m" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2r9m, resolution 1.97Å" /> | ||
| - | '''Cathepsin S complexed with Compound 15'''<br /> | ||
| - | == | + | ==Cathepsin S complexed with Compound 15== |
| - | + | <StructureSection load='2r9m' size='340' side='right'caption='[[2r9m]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2r9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9M FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y11:N-[(1S)-2-[(4-CYANO-1-METHYLPIPERIDIN-4-YL)AMINO]-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y11</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9m OCA], [https://pdbe.org/2r9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9m RCSB], [https://www.ebi.ac.uk/pdbsum/2r9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9m ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9m_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9m ConSurf]. | |
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| - | + | ==See Also== | |
| + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bekkali Y]] | ||
| + | [[Category: Brown ML]] | ||
| + | [[Category: Capolino A]] | ||
| + | [[Category: Crane KM]] | ||
| + | [[Category: DeTuri M]] | ||
| + | [[Category: Emmanuel MJ]] | ||
| + | [[Category: Freeman D]] | ||
| + | [[Category: Frye LL]] | ||
| + | [[Category: Girardot M]] | ||
| + | [[Category: Grygon CA]] | ||
| + | [[Category: Hao M-H]] | ||
| + | [[Category: Hrapchak M]] | ||
| + | [[Category: Labadia ME]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Morwick T]] | ||
| + | [[Category: Nelson R]] | ||
| + | [[Category: Peterson JD]] | ||
| + | [[Category: Raymond EL]] | ||
| + | [[Category: Spero DM]] | ||
| + | [[Category: Thomson DS]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Ward YD]] | ||
| + | [[Category: White A]] | ||
| + | [[Category: White DM]] | ||
| + | [[Category: Wildeson J]] | ||
| + | [[Category: Young ERR]] | ||
| + | [[Category: Zindell R]] | ||
Current revision
Cathepsin S complexed with Compound 15
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Categories: Homo sapiens | Large Structures | Bekkali Y | Brown ML | Capolino A | Crane KM | DeTuri M | Emmanuel MJ | Freeman D | Frye LL | Girardot M | Grygon CA | Hao M-H | Hrapchak M | Labadia ME | Liu W | Morwick T | Nelson R | Peterson JD | Raymond EL | Spero DM | Thomson DS | Wang Y | Ward YD | White A | White DM | Wildeson J | Young ERR | Zindell R
