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2r9m
From Proteopedia
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| - | [[Image:2r9m.jpg|left|200px]] | ||
| - | + | ==Cathepsin S complexed with Compound 15== | |
| - | + | <StructureSection load='2r9m' size='340' side='right'caption='[[2r9m]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | | | + | <table><tr><td colspan='2'>[[2r9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9M FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y11:N-[(1S)-2-[(4-CYANO-1-METHYLPIPERIDIN-4-YL)AMINO]-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y11</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9m OCA], [https://pdbe.org/2r9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9m RCSB], [https://www.ebi.ac.uk/pdbsum/2r9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9m ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9m_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9m ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bekkali | + | [[Category: Bekkali Y]] |
| - | [[Category: Brown | + | [[Category: Brown ML]] |
| - | [[Category: Capolino | + | [[Category: Capolino A]] |
| - | [[Category: Crane | + | [[Category: Crane KM]] |
| - | [[Category: DeTuri | + | [[Category: DeTuri M]] |
| - | [[Category: Emmanuel | + | [[Category: Emmanuel MJ]] |
| - | [[Category: Freeman | + | [[Category: Freeman D]] |
| - | [[Category: Frye | + | [[Category: Frye LL]] |
| - | [[Category: Girardot | + | [[Category: Girardot M]] |
| - | [[Category: Grygon | + | [[Category: Grygon CA]] |
| - | [[Category: Hao | + | [[Category: Hao M-H]] |
| - | [[Category: Hrapchak | + | [[Category: Hrapchak M]] |
| - | [[Category: Labadia | + | [[Category: Labadia ME]] |
| - | [[Category: Liu | + | [[Category: Liu W]] |
| - | [[Category: Morwick | + | [[Category: Morwick T]] |
| - | [[Category: Nelson | + | [[Category: Nelson R]] |
| - | [[Category: Peterson | + | [[Category: Peterson JD]] |
| - | [[Category: Raymond | + | [[Category: Raymond EL]] |
| - | [[Category: Spero | + | [[Category: Spero DM]] |
| - | [[Category: Thomson | + | [[Category: Thomson DS]] |
| - | [[Category: Wang | + | [[Category: Wang Y]] |
| - | [[Category: Ward | + | [[Category: Ward YD]] |
| - | [[Category: White | + | [[Category: White A]] |
| - | [[Category: White | + | [[Category: White DM]] |
| - | [[Category: Wildeson | + | [[Category: Wildeson J]] |
| - | [[Category: Young | + | [[Category: Young ERR]] |
| - | [[Category: Zindell | + | [[Category: Zindell R]] |
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Current revision
Cathepsin S complexed with Compound 15
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Categories: Homo sapiens | Large Structures | Bekkali Y | Brown ML | Capolino A | Crane KM | DeTuri M | Emmanuel MJ | Freeman D | Frye LL | Girardot M | Grygon CA | Hao M-H | Hrapchak M | Labadia ME | Liu W | Morwick T | Nelson R | Peterson JD | Raymond EL | Spero DM | Thomson DS | Wang Y | Ward YD | White A | White DM | Wildeson J | Young ERR | Zindell R
