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2rey

From Proteopedia

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[[Image:2rey.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)==
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|PDB= 2rey |SIZE=350|CAPTION= <scene name='initialview01'>2rey</scene>, resolution 1.55&Aring;
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<StructureSection load='2rey' size='340' side='right'caption='[[2rey]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2rey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REY FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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|GENE= DVL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rey OCA], [https://pdbe.org/2rey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rey RCSB], [https://www.ebi.ac.uk/pdbsum/2rey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rey ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)'''
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[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2REY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REY OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rey_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rey ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Cooper, C.]]
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[[Category: Cooper C]]
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[[Category: Delft, F von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Turnbull A]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Turnbull, A.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: bound peptide]]
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[[Category: cytoplasm]]
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[[Category: developmental protein]]
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[[Category: domain]]
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[[Category: gene regulation]]
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[[Category: pdz]]
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[[Category: peptide binding site]]
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[[Category: phosphorylation]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:33 2008''
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Current revision

Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)

PDB ID 2rey

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