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2rf0

From Proteopedia

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(New page: 200px<br /> <applet load="2rf0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2rf0, resolution 2.00&Aring;" /> '''Crystal structure o...)
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[[Image:2rf0.gif|left|200px]]<br />
 
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<applet load="2rf0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2rf0, resolution 2.00&Aring;" />
 
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'''Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain'''<br />
 
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==Disease==
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==Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain==
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Known disease associated with this structure: Leukemia, transient, of Down syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=159595 159595]]
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<StructureSection load='2rf0' size='340' side='right'caption='[[2rf0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf0 OCA], [https://pdbe.org/2rf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/M3K10_HUMAN M3K10_HUMAN] Activates the JUN N-terminal pathway (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf0 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2RF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EDO as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA].
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*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C.H.]]
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[[Category: Berridge G]]
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[[Category: Berridge, G.]]
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[[Category: Edwards AM]]
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[[Category: Delft, F.von.]]
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[[Category: Elkins J]]
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[[Category: Edwards, A.M.]]
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[[Category: Eswaran J]]
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[[Category: Elkins, J.]]
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[[Category: Keates T]]
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[[Category: Eswaran, J.]]
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[[Category: Knapp S]]
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[[Category: Keates, T.]]
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[[Category: Pike ACW]]
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[[Category: Knapp, S.]]
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[[Category: Savitsky P]]
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[[Category: Pike, A.C.W.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Ugochukwu E]]
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[[Category: Savitsky, P.]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt, J.]]
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[[Category: EDO]]
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[[Category: atp-binding]]
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[[Category: map3k10]]
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[[Category: mkn28]]
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[[Category: mlk2]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: sgc]]
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[[Category: sh3 domain]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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[[Category: tkl kinase]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:37:07 2007''
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Current revision

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

PDB ID 2rf0

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