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2ypn

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==Hydroxymethylbilane synthase==
==Hydroxymethylbilane synthase==
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<StructureSection load='2ypn' size='340' side='right' caption='[[2ypn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2ypn' size='340' side='right'caption='[[2ypn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ypn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ypn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylbilane_synthase Hydroxymethylbilane synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.61 2.5.1.61] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypn OCA], [http://pdbe.org/2ypn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ypn RCSB], [http://www.ebi.ac.uk/pdbsum/2ypn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypn OCA], [https://pdbe.org/2ypn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypn RCSB], [https://www.ebi.ac.uk/pdbsum/2ypn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI]] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
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[https://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Hydroxymethylbilane synthase]]
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[[Category: Large Structures]]
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[[Category: Campbell, J W]]
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[[Category: Campbell JW]]
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[[Category: Habash, J]]
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[[Category: Habash J]]
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[[Category: Haedener, A]]
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[[Category: Haedener A]]
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[[Category: Hao, Q]]
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[[Category: Hao Q]]
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[[Category: Helliwell, J R]]
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[[Category: Helliwell JR]]
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[[Category: Nieh, Y P]]
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[[Category: Nieh YP]]
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[[Category: Raftery, J]]
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[[Category: Raftery J]]
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[[Category: Schotte, F]]
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[[Category: Schotte F]]
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[[Category: Ursby, T]]
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[[Category: Ursby T]]
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[[Category: Weisgerber, S]]
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[[Category: Weisgerber S]]
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[[Category: Wulff, M]]
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[[Category: Wulff M]]
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[[Category: All alpha/beta]]
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[[Category: Biosynthesis of linear tetrapyrrole]]
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[[Category: Transferase]]
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Current revision

Hydroxymethylbilane synthase

PDB ID 2ypn

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