This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3b7x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:04, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3b7x.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of human FK506-Binding Protein 6==
-
|PDB= 3b7x |SIZE=350|CAPTION= <scene name='initialview01'>3b7x</scene>, resolution 2.10&Aring;
+
<StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7X FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
|GENE= FKBP6, FKBP36 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Disease ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [http://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB]</span>
+
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
-
}}
+
== Function ==
 +
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] PPIases accelerate the folding of proteins.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7x_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7x ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of human FK506-Binding Protein 6'''
+
==See Also==
-
 
+
*[[FKBP 3D structures|FKBP 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
3B7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Peptidylprolyl isomerase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Bochkarev A]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Butler-Cole C]]
-
[[Category: Butler-Cole, C.]]
+
[[Category: Davis T]]
-
[[Category: Davis, T.]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Paramanathan R]]
-
[[Category: Paramanathan, R.]]
+
[[Category: Walker JR]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Weigelt J]]
-
[[Category: Walker, J R.]]
+
-
[[Category: Weigelt, J.]]
+
-
[[Category: isomerase]]
+
-
[[Category: repeat]]
+
-
[[Category: rotamase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics consortium]]
+
-
[[Category: tpr repeat]]
+
-
[[Category: williams-beuren syndrome]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:23:55 2008''
+

Current revision

Crystal structure of human FK506-Binding Protein 6

PDB ID 3b7x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b7x"
Personal tools