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3bgj

From Proteopedia

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[[Image:3bgj.png|left|200px]]
 
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{{STRUCTURE_3bgj| PDB=3bgj | SCENE= }}
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==Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 6-iodo-UMP==
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<StructureSection load='3bgj' size='340' side='right'caption='[[3bgj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 6-iodo-UMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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[[3bgj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGJ OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgj OCA], [https://pdbe.org/3bgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgj RCSB], [https://www.ebi.ac.uk/pdbsum/3bgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgj ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Bello, A M.]]
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[[Category: Bello AM]]
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[[Category: Devalla, S.]]
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[[Category: Devalla S]]
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[[Category: Kotra, L P.]]
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[[Category: Kotra LP]]
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[[Category: Liu, Y.]]
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[[Category: Liu Y]]
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[[Category: Pai, E F.]]
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[[Category: Pai EF]]
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[[Category: Tang, H L.]]
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[[Category: Tang HL]]
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[[Category: 6-iodo-ump]]
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[[Category: C-terminal domain]]
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[[Category: Disease mutation]]
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[[Category: Glycosyltransferase]]
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[[Category: Human]]
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[[Category: Lyase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Orotidine 5'-monophosphate decarboxylase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Transferase]]
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[[Category: Ump synthase]]
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Current revision

Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 6-iodo-UMP

PDB ID 3bgj

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