3byi

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[[Image:3byi.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)==
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|PDB= 3byi |SIZE=350|CAPTION= <scene name='initialview01'>3byi</scene>, resolution 2.250&Aring;
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<StructureSection load='3byi' size='340' side='right'caption='[[3byi]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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|GENE= ARHGAP15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byi OCA], [https://pdbe.org/3byi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byi RCSB], [https://www.ebi.ac.uk/pdbsum/3byi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byi ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHG15_HUMAN RHG15_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.<ref>PMID:12650940</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3byi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3byi ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)'''
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==See Also==
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*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3BYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Shrestha L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tickle J]]
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[[Category: Shrestha, L.]]
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[[Category: Ugochukwu E]]
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[[Category: Tickle, J.]]
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[[Category: Uppenberg J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: arhgap15]]
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[[Category: bm046]]
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[[Category: rho gtpase]]
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[[Category: sgc]]
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[[Category: signaling protein]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:01:47 2008''
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Current revision

Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)

PDB ID 3byi

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OCA

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