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3byi
From Proteopedia
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==Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)== | ==Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)== | ||
| - | <StructureSection load='3byi' size='340' side='right' caption='[[3byi]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='3byi' size='340' side='right'caption='[[3byi]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYI FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byi OCA], [https://pdbe.org/3byi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byi RCSB], [https://www.ebi.ac.uk/pdbsum/3byi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byi ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RHG15_HUMAN RHG15_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.<ref>PMID:12650940</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3byi_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3byi_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3byi ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3byi ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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| + | ==See Also== | ||
| + | *[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Burgess-Brown N]] |
| - | [[Category: Doyle | + | [[Category: Doyle D]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Johansson | + | [[Category: Johansson C]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh K]] |
| - | [[Category: Papagrigoriou | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Pike | + | [[Category: Pike ACW]] |
| - | + | [[Category: Shrestha L]] | |
| - | [[Category: Shrestha | + | [[Category: Tickle J]] |
| - | [[Category: Tickle | + | [[Category: Ugochukwu E]] |
| - | [[Category: Ugochukwu | + | [[Category: Uppenberg J]] |
| - | [[Category: Uppenberg | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Burgess-Brown N | Doyle D | Edwards AM | Elkins J | Johansson C | Kavanagh K | Papagrigoriou E | Pike ACW | Shrestha L | Tickle J | Ugochukwu E | Uppenberg J | Weigelt J | Von Delft F
