3c4z

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{{Seed}}
 
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[[Image:3c4z.png|left|200px]]
 
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==Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A==
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The line below this paragraph, containing "STRUCTURE_3c4z", creates the "Structure Box" on the page.
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<StructureSection load='3c4z' size='340' side='right'caption='[[3c4z]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C4Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3c4z| PDB=3c4z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c4z OCA], [https://pdbe.org/3c4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c4z RCSB], [https://www.ebi.ac.uk/pdbsum/3c4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c4z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRK1_BOVIN GRK1_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).[UniProtKB:Q9WVL4]<ref>PMID:12686556</ref> <ref>PMID:16675451</ref> <ref>PMID:21299498</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/3c4z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c4z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins. Here we report six crystal structures of rhodopsin kinase (GRK1), revealing not only three distinct nucleotide-binding states of a GRK but also two key structural elements believed to be involved in the recognition of activated GPCRs. The first is the C-terminal extension of the kinase domain, which was observed in all nucleotide-bound GRK1 structures. The second is residues 5-30 of the N terminus, observed in one of the GRK1.(Mg2+)2.ATP structures. The N terminus was also clearly phosphorylated, leading to the identification of two novel phosphorylation sites by mass spectral analysis. Co-localization of the N terminus and the C-terminal extension near the hinge of the kinase domain suggests that activated GPCRs stimulate kinase activity by binding to this region to facilitate full closure of the kinase domain.
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===Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A===
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Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.,Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ J Biol Chem. 2008 May 16;283(20):14053-62. Epub 2008 Mar 13. PMID:18339619<ref>PMID:18339619</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3c4z" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18339619}}, adds the Publication Abstract to the page
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*[[Rhodopsin kinase|Rhodopsin kinase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18339619 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18339619}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3C4Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C4Z OCA].
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==Reference==
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Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation., Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ, J Biol Chem. 2008 May 16;283(20):14053-62. Epub 2008 Mar 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18339619 18339619]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Rhodopsin kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Singh P]]
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[[Category: Singh, P.]]
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[[Category: Tesmer JJG]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Adp]]
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[[Category: Atp-binding]]
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[[Category: Autophosphorylation]]
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[[Category: G protein coupled receptor kinase]]
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[[Category: Grk]]
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[[Category: Grk1]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Methylation]]
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[[Category: Nucleotide-binding]]
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[[Category: P-loop]]
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[[Category: Phosphoprotein]]
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[[Category: Prenylation]]
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[[Category: Rgs homology domain]]
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[[Category: Rhodopsin kinase]]
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[[Category: Ser/thr kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:46:09 2008''
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Current revision

Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A

PDB ID 3c4z

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