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3c57

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==Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain Crystal Form II==
==Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain Crystal Form II==
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<StructureSection load='3c57' size='340' side='right' caption='[[3c57]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3c57' size='340' side='right'caption='[[3c57]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3c57]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C57 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3c57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C57 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c3w|3c3w]], [[1zlj|1zlj]], [[1zlk|1zlk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">devR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c57 OCA], [https://pdbe.org/3c57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c57 RCSB], [https://www.ebi.ac.uk/pdbsum/3c57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c57 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c57 OCA], [http://pdbe.org/3c57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c57 RCSB], [http://www.ebi.ac.uk/pdbsum/3c57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c57 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DEVR_MYCTO DEVR_MYCTO]] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response.
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[https://www.uniprot.org/uniprot/DEVR_MYCTU DEVR_MYCTU] Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormancy response (PubMed:15033981). Regulates an approximately 48-member regulon (PubMed:12953092, PubMed:11416222, PubMed:15033981, PubMed:18400743). When phosphorylated binds and activates the promoter of DevR regulon genes in response to hypoxia (PubMed:18359816, PubMed:21764934, PubMed:28977726). The presence of target DNA increases stability of phospho-DevR in vitro (PubMed:28977726). Activates its own transcription under hypoxic but not aerobic conditions, probably binds as a dimer to tandem binding sites within the devR and hspX promoters (PubMed:18359816). Accepts a phosphate group from DevS (DosS) and from DosT (PubMed:15033981, PubMed:15073296, PubMed:21764934, PubMed:28977726). Does not regulate transcription of dosT (PubMed:19487478).<ref>PMID:11416222</ref> <ref>PMID:12953092</ref> <ref>PMID:15033981</ref> <ref>PMID:15073296</ref> <ref>PMID:18359816</ref> <ref>PMID:18400743</ref> <ref>PMID:19487478</ref> <ref>PMID:21764934</ref> <ref>PMID:28977726</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Response regulator|Response regulator]]
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*[[Response regulator 3D structure|Response regulator 3D structure]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hol, W G.J]]
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[[Category: Large Structures]]
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[[Category: Sherman, D R]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Wisedchaisri, G]]
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[[Category: Hol WGJ]]
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[[Category: Wu, M]]
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[[Category: Sherman DR]]
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[[Category: Dna-binding protein]]
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[[Category: Wisedchaisri G]]
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[[Category: Response regulator]]
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[[Category: Wu M]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Tuberculosis]]
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[[Category: Two-component regulatory system]]
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Current revision

Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain Crystal Form II

PDB ID 3c57

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