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3ce5

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{{Seed}}
 
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[[Image:3ce5.png|left|200px]]
 
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==A bimolecular parallel-stranded human telomeric quadruplex in complex with a 3,6,9-trisubstituted acridine molecule BRACO19==
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The line below this paragraph, containing "STRUCTURE_3ce5", creates the "Structure Box" on the page.
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<StructureSection load='3ce5' size='340' side='right'caption='[[3ce5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ce5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CE5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRA:9-[4-(N,N-DIMETHYLAMINO)PHENYLAMINO]-3,6-BIS(3-PYRROLIDINOPROPIONAMIDO)+ACRIDINE'>BRA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_3ce5| PDB=3ce5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ce5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ce5 OCA], [https://pdbe.org/3ce5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ce5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ce5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ce5 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands
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===A bimolecular parallel-stranded human telomeric quadruplex in complex with a 3,6,9-trisubstituted acridine molecule BRACO19===
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Structural basis of DNA quadruplex recognition by an acridine drug.,Campbell NH, Parkinson GN, Reszka AP, Neidle S J Am Chem Soc. 2008 May 28;130(21):6722-4. Epub 2008 May 6. PMID:18457389<ref>PMID:18457389</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ce5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18457389 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18457389}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3CE5 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CE5 OCA].
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[[Category: Campbell NH]]
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[[Category: Neidle S]]
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==Reference==
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[[Category: Parkinson GN]]
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Structural basis of DNA quadruplex recognition by an acridine drug., Campbell NH, Parkinson GN, Reszka AP, Neidle S, J Am Chem Soc. 2008 May 28;130(21):6722-4. Epub 2008 May 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18457389 18457389]
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[[Category: Reszka AP]]
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[[Category: Single protein]]
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[[Category: Campbell, N H.]]
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[[Category: Neidle, S.]]
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[[Category: Parkinson, G N.]]
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[[Category: Reszka, A P.]]
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[[Category: Acridine]]
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[[Category: Bimolecular]]
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[[Category: Braco19]]
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[[Category: Complex]]
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[[Category: Dna]]
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[[Category: Human]]
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[[Category: Parallel]]
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[[Category: Quadruplex]]
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[[Category: Telomere]]
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[[Category: Trisubstituted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:07:56 2008''
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Current revision

A bimolecular parallel-stranded human telomeric quadruplex in complex with a 3,6,9-trisubstituted acridine molecule BRACO19

PDB ID 3ce5

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