This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3cii

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:28, 30 August 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of NKG2A/CD94 bound to HLA-E==
==Structure of NKG2A/CD94 bound to HLA-E==
-
<StructureSection load='3cii' size='340' side='right' caption='[[3cii]], [[Resolution|resolution]] 4.41&Aring;' scene=''>
+
<StructureSection load='3cii' size='340' side='right'caption='[[3cii]], [[Resolution|resolution]] 4.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3cii]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CII FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3cii]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CII FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HLA-E, HLA-6.2, HLAE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KLRD1, CD94 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KLRC1, NKG2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.41&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cii OCA], [http://pdbe.org/3cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cii RCSB], [http://www.ebi.ac.uk/pdbsum/3cii PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cii OCA], [https://pdbe.org/3cii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cii RCSB], [https://www.ebi.ac.uk/pdbsum/3cii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cii ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. [[http://www.uniprot.org/uniprot/HLAE_HUMAN HLAE_HUMAN]] Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. [[http://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN]] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/NKG2A_HUMAN NKG2A_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
+
[https://www.uniprot.org/uniprot/HLAE_HUMAN HLAE_HUMAN] Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/3cii_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/3cii_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 30:
==See Also==
==See Also==
-
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
*[[Major histocompatibility complex|Major histocompatibility complex]]
+
*[[MHC 3D structures|MHC 3D structures]]
 +
*[[MHC I 3D structures|MHC I 3D structures]]
*[[NK cell receptor|NK cell receptor]]
*[[NK cell receptor|NK cell receptor]]
== References ==
== References ==
Line 38: Line 38:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Kaiser, B K]]
+
[[Category: Large Structures]]
-
[[Category: Pizarro, J C]]
+
[[Category: Kaiser BK]]
-
[[Category: Strong, R K]]
+
[[Category: Pizarro JC]]
-
[[Category: C-type lectin-like]]
+
[[Category: Strong RK]]
-
[[Category: Disease mutation]]
+
-
[[Category: Glycation]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Immune response]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunoglobulin domain]]
+
-
[[Category: Lectin]]
+
-
[[Category: Membrane]]
+
-
[[Category: Mhc i]]
+
-
[[Category: Pyrrolidone carboxylic acid]]
+
-
[[Category: Receptor]]
+
-
[[Category: Secreted]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Transmembrane]]
+

Current revision

Structure of NKG2A/CD94 bound to HLA-E

PDB ID 3cii

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cii"
Personal tools